Prepare the potatoes by washing and cutting them into wedges.
Soak the potato wedges in buttermilk for at least 30 minutes.
Combine flour, garlic powder, onion powder, smoked paprika, salt, and black pepper in a large bowl.
Heat oil in a deep fryer or large pot to 350°F (175°C).
Coat the soaked potato wedges in the seasoned flour mixture.
Carefully place the coated wedges into the hot oil, frying them in small batches.
Allow the wedges to cool slightly and sprinkle with additional salt, if desired.